Best Practices for Tnew and Mail2 Integration

We're starting our implementation of Tnew and Mail2 and are wondering the best ways to integrate the system and acquire email addresses. So far we are looking at using Interests or the Mailing List Preference Tab. Does anyone have experience with these that could tell me some of the positive or negatives for each method?

Thanks,
Grace

Grace Geller
American Repertory Theater | Marketing and Communications Manager